Acute febrile illness with thrombocytopenia is a common condition associated with an increased risk of morbidityand mortality. India is a lower-middle-income country (LMIC), with approximately 70% of its population living in rural areas.Thrombocytopenia may be defined as a subnormal number of platelets in the circulating blood. Longer hospital stays in theintensive care unit (ICU), more bleeding events, more transfusions needed, and higher mortality are all associated withthrombocytopenia. Our study aims to observe clinical and laboratory parameters in patients with acute febrile illness withthrombocytopenia in a tertiary care centre. This cross-sectional study was carried out at a tertiary care teaching hospital. Weincluded 125 patients with thrombocytopenia who were ≥18 years of age between March 2022 and December 2022. Thepatients were observed and followed up during their stay in the hospital, diagnoses were made, and bleeding manifestations andplatelet transfusion requirements were recorded. Most patients were in the age group 26-35, with 31.2%. The male-to-femaleratio in our study was 1.3:1. Apart from fever, the most common symptom was myalgia (65.6%). Dengue was diagnosed in mostof the patients (56.8%). The platelet counts of <10000/ cum were observed in 22 patients, among which 14 showed bleedingmanifestations. Acute kidney injury was the most common complication in 24.8% of patients, followed by Hepatitis in 14.4%. Anearly diagnosis and targeted therapy for the underlying cause of febrile thrombocytopenia and maintenance of platelet count andhaemostatic function lead to an effective recovery.

1. Balli S, Sharan S. Physiology, fever. StatPearls [Internet]. Updated 2021Aug28:2022Jan-.
2. Joshi R, Colford JM, Reingold AL, Kalantri S. Nonmalarial acute undifferentiated fever in a rural Hospital in CentralIndia: diagnostic uncertainty and overtreatment with antimalarial agents. Am J Trop Med Hyg.2008;78(3):393-9. doi: 10.4269/ajtmh.2008.78.393, PMID 18337332.
3. AbhilashKP, JeevanJA, Mitra S, Paul N, MuruganTP, Rangaraj A, et al. Acute undifferentiated febrile illness in patients presenting to a tertiary Care Hospital in South India: clinical spectrum and outcome. J Glob Infect Dis.2016;8(4):147-54. doi: 10.4103/0974-777X.192966, PMID 27942194.
4. Leelarasamee A, Chupaprawan C, Chenchittikul M, Udompanthurat S. Etiologies of acute undifferentiated febrile illness in Thailand. J Med assoc Thail. 2004;87(5):464-72.
5. Gupta ED. Clinical features of acute thrombocytopaenia among patients attending primary care clinics. Malays Fam Physician. 2006;1(1):18. PMID 26998202.
6. Sumangala S, Biradar S, Ali MZ, Saudagar M. A study of clinical and laboratory evaluation and outcome of patients with acute febrile illness with thrombocytopenia.APIK J Int Med.2020;8(3):121-7. doi: 10.4103/AJIM.AJIM_44_19.
7. Barbara A, KonkleFauci AS, Braunwald E, Kasper DL, Longo DL, Jameson JL, et al. Disorders of platelets and vessel wall. In: Harrison’s principles of internalmedicine. New York: McGraw-Hill; 2015. p. 725-32.
8. Nair BT, Sharma K, Paimode SD. A study of clinical and laboratory profile of febrile children presenting with thrombocytopenia. Int J Contemp Pediatr.2017;4(6):2114-9. doi: 10.18203/2349-3291.ijcp20174742.
9. Li DX. Severe fever with thrombocytopenia syndrome: A newly discovered emerging infectious disease. Clin Microbiol Infect.2015;21(7):614-20. doi: 10.1016/j.cmi.2015.03.001, PMID 25769426.
10. Patne SV, Chintale KN. Clinical profile of patients with thrombocytopenia at tertiary health care centre. Int J Adv Med.2017;4(6):1551-6. doi: 10.18203/2349-3933.ijam20175082.
11. Kumar P, Chandra K. A clinicalstudy of febrilethrombocytopenia: A hospital-based retrospectivestudy.
12. Suneetha DK, Inbanathan J, Sahna E, Shashank MS. Common etiology of acute fever with thrombocytopenia in a tertiary care hospital Mysuru. Int J Sci Stud.2016;4:61-4.
13. Nair PS, Jain A, Khanduri U, Kumar V. A study of fever associated thrombocytopenia. JAPI. 2003; 51:1173.
14. Modi TN, Mehta AD, Sriram AS. Clinical profile of febrile thrombocytopenia: a hospital-based cross-sectional study. J Res Med Den Sci. 2016Apr1;4(2):115. doi: 10.5455/jrmds.2016428.
15. Akca S, Haji-Michael P, de Mendonça A, Suter P, Levi M, Vincent JL. Time course of platelet counts in critically ill patients. Crit Care Med.2002;30(4):753-6. doi: 10.1097/00003246-200204000-00005, PMID 11940740.
16. Strauss R, Wehler M, Mehler K, Kreutzer D, Koebnick C, Hahn EG. Thrombocytopenia in patients in the medical Intensive Care Unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med.2002;30(8):1765-71. doi: 10.1097/00003246-200208000-00015, PMID 12163790.
17. Bhaskar J, Sridhar C. Clinical outcome of acute febrile illness with thrombocytopenia among patients at tertiary care Hospital. IntJ Res Rev. 2021Feb;8(2):582-5.
18. Dhunputh P, Acharya R, Umakanth S, Shetty SM, Mohammed AP, Saraswat PP. Clinical profile of Thrombocytopenia in Acute Febrile Illnesses; a hospital-based study. Kathmandu Univ Med J (KUMJ).2021Apr1;19(74):248-52. doi: 10.3126/kumj.v19i2.49656, PMID 34819445.
19. Gondhali MP, Vethekar M, Bhangale D, Choudhary K, Chaudhary M, Patrike Get al.Clinical assessment of fever with thrombocytopenia-A prospective study. IntJ MedRes Health Sci. 2016Jan1;5(1):258-77.
20. Hariprasad S, Sukhani N. Evaluation of clinical profile of febrile thrombocytopenia: an institutional study. Int J Adv Med.2017;4(6):1502-5. doi: 10.18203/2349-3933.ijam20174674.