Diabetes mellitus(DM) is a global public health concern that is considered by prolonged hyperglycemia triggered by compromised insulin action or secretion. Numerous studies have shown a link between electrolyte intensities and diabetes. Therefore, this study aimed to investigate the association between fasting glucose in plasma and electrolytes and absorption electrolyte imbalances in individuals with type 2 diabetic ailments. High blood sugar (BS) injures the nephrons, affecting electrolyte exchange. The study enrolled 62 participants into two groups: the study group with Type 2 diabetes (Type 2) and consistently high random blood sugar levels (BSL) above 300 and the control group with lower BSLs. The findings suggest that higher blood glucose levels(BGL) are associated with increased potassium and chloride levels. In conclusion, individuals with Diabetes (Type 2) and BGL above 300 exhibits lower levels of sodium but higher serum potassium and chloride levels (PCL) compared to those with lower BGL. The study's results shed light on the potential electrolyte imbalances in individuals with Diabetes (Type 2), particularly those with poorly controlled BGL. Understanding these imbalances is crucial for healthcare providers to manage and treat diabetic patients effectively. This study provides valuable insights into the relationship among fasting plasma glucose (FPG), electrolyte levels, and Diabetes (Type 2). Further research is warranted to elucidate the underlying mechanisms and potential clinical implications of these electrolyte imbalances in individuals with diabetes.
Zimmet P, Alberti KG, Shaw J. global and societal implications of the diabetes epidemic. Nature. 2001;414:782-7.[PMID:11742409]
Thanpari C., Thakelmayum R & Kumar R. Correlation of Lipid Profiles, Electrolytes and Antioxidant Status In Type 2 Diabetic Patients With Hypertension In Sikkimese Population: A Case Controlled Study. Jour. Of Med. Sci. & Tech.1(2), pp 71-74.
Alberti K.G. and Zimmet P.. "Definition, diagnosis, and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO Consultation.” Diabet. Med. 1998; 15: 539-3.
King H. and Rewers M. “Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group.” Diabet. Care. 1993; 16: 157-7.
Hosen B, Buiyan AR, Hasan S, Hassan M, Uddin M. Estimation of Serum Electrolytes in non-Insulin Dependent (type 2) Diabetic Patients in Bangladesh, Scientific research journal (SCRJ). 2014;2(4):29-32.
Martini FH, Halyard RA. Fluid electrolytes and acid-base balance. In: Fundamentals of Anatomy and Physiology Interactive. (Media Edition) 4th ed; USA; Person Education, Inc. 1998.
Ojiako OA, Chikezie PC. Blood Na+/K+ and Cl- Levels of Hyperglycemic rats Administered with traditional Herbal Formulations, Pharmacognosy Communications. 2015;5(2):140-5.
Shahid SM, Rafique R, Mahboob T. Electrolytes and sodium transport mechanism in diabetes Pak. J Pharm. Sci. 2005; 18(2): 6-10.
Hosen B, Buiyan AR, Hasan S et al. Estimation of serum electrolytes in type 2 diabetic patients in Bangladesh: Scientific research journal 2014;12: 2201-2796.
Al-Jameil N. Estimation of Serum Electrolytes in Diabetes Patients of Saudi Region. Life. Sci. J. 2014; 11(7): 378-380.
Parmar SK, Singh S, Singh GK. Role of hyperglycemia in the pathogenesis of Na?/K? disturbance. International J Res Med Sci.2016 Apr:4(4):1167-1171.
Wang S, Xuhong H, Yu L et al. “Serum electrolytes relation to macrovascular complications in Chinese Patients with Diabetes mellitus.” Cardiovas. Diabet. 2013; 12: 146-55. 5- Rao GM. Serum electrolytes and osmolality in diabetes mellitus. Indian J Med Sci 1992;46(10):301-3.
Zimmet P, Alberti KG, Shaw J. global and societal implications of the diabetes epidemic. Nature. 2001;414:782-7.[PMID:11742409]
Thanpari C., Thakelmayum R & Kumar R. Correlation of Lipid Profiles, Electrolytes and Antioxidant Status In Type 2 Diabetic Patients With Hypertension In Sikkimese Population: A Case Controlled Study. Jour. Of Med. Sci. & Tech.1(2), pp 71-74.
Alberti K.G. and Zimmet P. Definition, diagnosis, and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO Consultation. Diabet. Med. 1998; 15: 539-3.
King H. and Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabet. Care. 1993; 16: 157-7.
Wang, S., Hou-Xuhong, H. Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus. Cardiovasc.Diabetol. 2013; 12 (146): 1-10.
Haglin, L., Backman., L., Tornkvist, B. A. Structural equation model for assessment of links between changes in serum triglycerides, urate, and glucose and changes in serum calcium, magnesium and phosphate in Type 2 diabetes and non-diabetes metabolism.Cardiovascular Diabetology journal.2011; 10 (75): 1-6.
Palmer, B.F., Clegg, D.J. “Electrolyte and Acid-Base Disturbances in Patients with Diabetes Mellitus. New England Journal of Medical. 2015; 373(6): 54-59.
Nabil, A., Hasona ,A. E. Evaluation of Electrolytes Imbalance and Dyslipidemia in Diabetic Patients.Medical Sciences journal. 2016; 4 (7): 1-4.
Chin MP, Reisman SA, Bakris GL, O'Grady M, Linde PG, McCullough PA, Packham D, Vaziri ND, Ward KW, Warnock DG, Meyer CJ. Mechanisms contributing to adverse cardiovascular events in patients with Type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl. American journal of nephrology. 2014 Jul 1;39(6):499-508.
Liamis G, Liberopoulos E, Barkas F, Elisaf M. Diabetes mellitus and electrolyte disorders. World Journal of Clinical Cases: WJCC. 2014 Oct 10;2(10):488.
Lytvyn Y, Škrti? M, Yang GK, Yip PM, Perkins BA, Cherney DZ. Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus. American Journal of Physiology-Renal Physiology. 2015 Jan 15;308(2):F77-83.
Adrogué HJ, Madias NE. The challenge of hyponatremia. Journal of the American Society of Nephrology. 2012 Jul 1;23(7):1140-8.
Knochel JP. The syndrome of hyporeninemic hypoaldosteronism. Annual Review of Medicine. 1979 Feb;30(1):145-53.
Weir MA, Juurlink DN, Gomes T, Mamdani M, Hackam DG, Jain AK, Garg AX. Beta-blockers, trimethoprim-sulfamethoxazole, and the risk of hyperkalemia requiring hospitalization in the elderly: a nested case-control study. Clinical Journal of the American Society of Nephrology: CJASN. 2010 Sep;5(9):1544.