International Journal of Pharma and Bio Sciences
    ISSN 0975-6299

Int J Pharm Bio Sci Volume 12 Issue 2, 2021 (April-June), Pages:106-113

Congenital Heart Disease in New Borns and Children, Clinical Features and Management- A Review

Dr.P.Paramanantham and Dr.P.S.SathulHak

Congenital heart disease / congenital heart defects are more common than anomalies of any other systems of the human body. These defects occur in-utero during the organogenesis period, particularly in 1st trimester and the congenital heart disease may occur subsequently during development of the baby due to various environmental, genetic and developmental growth of the heart upto 1 year of life and these defects or illnesses result in various clinical implications with clinical signs and symptoms for us to diagnose and give appropriate therapy. Most of the cyanotic congenital heart disease cyanosis develops at birth and some congenital heart disease particularly Fallot’s develop cyanosis late in the neonatal period. Most of the congenital heart disease respond to prostaglandin therapy, particularly this therapy is contraindicated in total anomalous pulmonary venous connection. This review explains the timing of referral of these CHD babies and children to the pediatric cardiologist and if necessary to pediatric cardiac surgeons. It is essential to know congenital heart disease forms a bulk which needs more pediatric cardiologists and pediatric cardiac surgeons. Only 200 pediatric cardiologists and 180 pediatric cardiac surgeons are available in the whole of India. Hence to give adequate care, proper identification and need for referral at an appropriate time is essential to decrease the morbidity and mortality in pediatric cardiac patients.

Keywords: congenital heart disease, congenital heart disease repair, congenital heart disease mortality, congenital heart disease surgical care.
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1.       Wren C, Richmond S, Donaldson L. Presentation of congenital heart disease in infancy: implications for routine examination. Arch Dis Child Fetal NeonatalEd.1999;80(1):F49-53. doi: 10.1136/fn.80.1.f49, PMID 10325813.

2.       HoffmanJIe. The global burden of congenital heart disease.Cardiovasc J Afr.2013;24(4):141-5. doi: 10.5830/CVJA-2013-028, PMID 24217047.

3.       Bernier PL, Stefanescu A, Samoukovic G, Tchervenkov CI. The challenge of congenital heart disease worldwide: epidemiologic and demographic facts. SeminThoracCardiovascSurgPediatr Card SurgAnnu.2010;13(1):26-34. doi: 10.1053/j.pcsu.2010.02.005, PMID 20307858.

4.       Saxena A, Mehta A, Sharma M, Salhan S, Kalaivani M, Ramakrishnan S, Juneja R. Birth prevalence of congenital heart disease: a cross-sectional observational study from North India. Ann PediatrCardiol.2016;9(3):205-9. doi: 10.4103/0974-2069.189122, PMID 27625516.

5.       PEDIATRICS, PAULVK, BAGGAA. GHAIessential.8thed. 2016;15:400-1.

6.       Sasidharan P. An approach to diagnosis and management of cyanosis and tachypnea in term infants.PediatrClin N Am.2004;51(4):999-1021, ix, ix, Ix. doi: 10.1016/j.pcl.2004.03.010, PMID 15275985.

7.       Park Mk. Cyanotic congenital heart defects. In:. In:PMk, editor. Park’s Pediatric Cardiology for Practitioners. 6thed. Philadelphia:ElsevierSaunders; 2014. p. 223.

8.       Craig JM, Darling RC, Rothney WB. Total pulmonary venous drainage into the right side of the heart; report of 17 autopsied cases not associated with other major cardiovascular anomalies. Lab Invest.1957;6(1):44-64. PMID 13386206.

9.       ZulfikarAhamed M, AbhilashTgSAZ. Approach to infants and children with cyanotic congenital heart diseases.Kerala Heart J.2015;5:30-5.

10.     Hoffman JI, Kaplan S. The incidence of congenital heart disease.J Am CollCardiol.2002;39(12):1890-900. doi: 10.1016/s0735-1097(02)01886-7, PMID 12084585.

11.     Tikanoja T. Effect of technical development on the apparent incidence of congenital heart disease. PediatrCardiol.1995;16(2):100-1. doi: 10.1007/BF00796830, PMID 7784232.

12.     Wood P. The Eisenmengersyndrome: II. BMJ.1958;2(5099):755-62. doi: 10.1136/bmj.2.5099.755.

13.     Sacchetti A, Moyer V, Baricella R, Cameron J, Moakes ME. Primary cardiac arrhythmias in children.PediatrEmerg Care.1999;15(2):95-8. doi: 10.1097/00006565-199904000-00004, PMID 10220076.

14.     Doniger SJ, Sharieff GQ. Pediatric dysrhythmias.PediatrClin N Am.2006;53(1):85-105, vi, vi, Vi. doi: 10.1016/j.pcl.2005.10.004, PMID 16487786.

15.     Losek JD, Endom E, Dietrich A, Stewart G, Zempsky W, Smith K. Adenosine and pediatric supraventricular tachycardia in the Emergency Department: multicenter study and review. Ann EmergMed.1999;33(2):185-91. doi: 10.1016/s0196-0644(99)70392-6, PMID 9922414.

16.     Nadas AS, Daeschner CW, Roth A, Blumenthal SL. Paroxysmal tachycardia in infants and children; study of 41 cases. Pediatrics.1952;9(2):167-81. PMID 14911279.

17.     Perry JC, Garson A. Supraventricular tachycardia due to Wolff–Parkinson–White syndrome in children: early disappearance and late recurrence. J Am CollCardiol.1990;16(5):1215-20. doi: 10.1016/0735-1097(90)90555-4, PMID 2229769.

18.     Salerno JC, Seslar SP. SalernoJc, Seslar sp. [supraventricular tachycardia]. Arch PediatrAdolescMed.2009;163(3):268-74. doi: 10.1001/archpediatrics.2008.547, PMID 19255396.

19.     CaviedesBottner P, CórdovaFernández T, Larraín Valenzuela M, Cruces Romero Presentación de CasosClínicos P. Dilated cardiomyopathy and severe heart failure. An update for pediatricians.Arch Argent Pediatr.2018;116(3):e421-8. doi: 10.5546/aap.2018.eng.e421, PMID 29756716.

20.     Schweigmann U, Meierhofer C. Strategies for the treatment of acute heart failure in children. Minerva Cardioangiol.2008;56(3):321-33. PMID 18509293.

21.     Epstein AE, Dimarco JP, Ellenbogen KA, Estes NA, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO, American College of Cardiology/American Heart Association Task Force on Practice, American Association for Thoracic Surgery, Society of Thoracic Surgeons, American Association for Thoracic Surgery, Society of Thoracic Surgeons. Acc/aha/Hrs2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summary. Heart Rhythm.2008;5(6):934-55. doi: 10.1016/j.hrthm.2008.04.015, PMID 18534377.

22.     Pillekamp F, Khalil M, Emmel M, Brockmeier K, Hescheler J. Stem cells in pediatric heart failure. Minerva Cardioangiol.2008;56(3):335-48. PMID 18509294.

23.     Moss AJ, Adams FH, Allen HD, et al. Moss and Adams’ heart disease in infants, children, and adolescents: including the fetus and young adult. Philadelphia: Wolters Kluwer; 2016.

24.     Freeman SB, Taft LF, Dooley KJ, Allran K, Sherman SL, Hassold TJ, Khoury MJ, Saker DM. Population-based study of congenital heart defects in down syndrome. Am J Med Genet.1998;80(3):213-7. doi: 10.1002/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8, PMID 9843040.

25.     Frescura C, Thiene G, Franceschini E, Talenti E, Mazzucco A. Pulmonary vascular disease in infants with complete atrioventricularseptal defect. Int J Cardiol.1987;15(1):91-103. doi: 10.1016/0167-5273(87)90295-6, PMID 2952609.

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