The oral route of administration is the common pathway for the delivery of drugs, but delivery of lipophilic compounds has a key provocation because of their poor aqueous solubility. From the last few decades, a keen interest in the development of lipid based formulation for the delivery of challenging lipophilic/hydrophobic drug compounds has been observed. Self emulsifying drug delivery system (SEDDS) as lipid based formulation helps to enhance the oral absorption of hydrophobic and lipid loving drugs. SEDDS are isotropic mixture of triglycerides (oils), surfactant, co-surfactants and solvents. The absorption of orally administered drug from the lipid based (SEDDS) formulation depends upon many factors such as oil/surfactant proportion, polarity and size of droplet which in essence the ability of self emulsification. This review, focuses on the different excipients such as oil, surfactants and cosolvents, selection of excipients for SEDDS formulation and mechanism of self emulsification. Moreover, this review highlights the solidification of liquid/ semi solid SEDDS by different approaches such as absorption on to solid carrier, spray dying, melt extrusion and extrusion spherionization. These types of solid-lipid technologies appear very attractive and make the process of handling and easy transportation of liquid SEDDS. The solid-SEDDS can also be encapsulated in hard and soft gelatin capsules. This article also focuses on future aspects and different new techniques for the analysis s-SEDDS.

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