To  partially  assess  the  efficacy of  probiotic  lozenges, in  the  treatment  of   periodontal  disease. Material and methods: Twenty eight subjects, of both sexes, were selected and divided into 4 groups (2 test groups and 2 control groups).The  test  group was  instructed  to  consume  probiotic  lozenges whereas the control  group did  not  receive  any  probiotic  product. Clinical  parameters such as plaque  index, gingival  index, modified sulcular bleeding  index  and  probing pocket  depth were  recorded and assessed  at  baseline, day 15, 30, 45 and day 60. The Test  group  showed  significant  reduction  in  all  parameters  when  compared  to  that  of  Control  group. After stopping probiotic administration on day 30, the test group showed a significant increase in all the clinical parameters except probing pocket depth on day 45 and day 60. Conclusions: The  results show that  probiotic  lozenges  were  efficacious  in  reducing  both  moderate  to  severe  gingivitis  and  moderate  periodontitis.