The country-wide shortage of medical teachers in several pre- and para-clinical disciplines, calls for development of ‘stand-alone’ teaching modules which can replace them, wherever at all possible: our Microbiology department put together audio-visual power-point slides for one module of topics. These “teacher-less” classes were conducted for a batch of undergraduate students, in a case-control randomized format of study. Results of their attitude (qualitative) and performance scores (quantitative) were tabulated and analyzed and are presented here. Comparative literature is also discussed.