Herbal concoctions have recently been investigated for various chronic and complicated ailments as effective therapeutics. The Ayurvedic literature of India is essentially focussed for their biologically active constituents in whole for efficacy. In this study, a preliminary analysis of the rhizomes of Acorus calamus L, has been investigated as a potent antitumour agent against Daltons Ascites Lymphoma in mice by evaluating the tumour growth, toxicity and haematological parameters. The methanolic extract of Acorus calamus (MEAC) was observed to restore the hematological parameters as compared with the DAL bearing mice in a dose dependant manner indicating a significant antitumour activity, thus indicating A. calamus to be a potent ethnomedicine.