Tabebuia rosea is one of the medicinally important plant belonging to the family Bignoniaceae. Tabebuia species are native to tropical rain forests throughout central and South America. The objective of the present study was to evaluate and compare the Anthelmintic activity of methanolic extract of leaves of Tabebuia rosea Bertol DC. (Bignoniaceae). Albendazole was used as a standard drug to compare the test results. Indian Adult earth worms (Pheretima posthuma) were used for the study. The results were interpreted as time taken for paralysis and death of the earth worms. The study concluded that the methanolic leaf extract of Tabebuia rosea showed significant Anthelmintic activity.