In the present study of chloroform extract of leaves of Flaveria trinervia (Sprengel) C.Mohr. (Asteraceae) obtained by soxhlet extraction method was tested for anti-inflammatory activity by carrageenan induced paw edema in rats. The chloroform extract in dose of 250mg /kg b.w was administered orally.Anti- inflammatory activity effect was compared with standard drug – Indomethacin (10mg/kg b.w) showed 31% and 51% inhibition of paw edema, in extract and standard respectively. These observations help us to conclude that chloroform extract has showed good anti- inflammatory activity against carrageenan induced paw edema.