Effect Of A Polyherbal Formulation On Ethylene Glycol Induced Urolithiasis.
Keywords:
Urolithiasis; Poly herbal formulation; Ethylene glycol; Ammonium chloride, urinary stone inhibitors.Abstract
Antiurolithic effect of aqueous extract of Terminalia chebula, Glycyrrhiza glabra, Nelumbo nucifera, Zingiber officinale, Hemidesmus indicus, Myristica fragrans and Citrus aurantofolia. was tested. 24 albino wistar rats were divided into 4 groups of 6 each. Group-I is control. Groups-II, III and IV were fed 0.75% ethylene glycol by gastric lavage and 1 gm Ammonium chloride in drinking water . Groups-III and IV received aqueous extract of polyherbal formulation at a dose of 1mg/kg body weight and 2mg/kg body weight. . Statistical Analysis: One way of Analysis of Variance was used to test the statistical significance. Results.In urolithiatic animals,Calcium and Oxalate excretion was grossly increased. Groups III & IV showed weight gain, decreased calcium and oxalate excretion, increased levels of urinary volume , pH and stone inhibitors. Histopathological examination of renal tissues confirms this result. Conclusion: The polyherbal formulation used in this study has preventive effect in the formation of renal calculi.
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