Evaluation Of Oxidative Stress And Antioxidant Status In Patients With Epilepsy

Authors

  • RAKESH MUDARADDI Department of Biochemistry, SDMCMSH, Dharwad, Karnataka, India.
  • RAMESH Department of Biochemistry, RIMS, Raichur, Karnataka, India.
  • SAMEER Department of Biochemistry, Sikkim Manipal IMS, Gangtok, Sikkim, India.
  • AMARESHWARA M Department of Biochemistry, VIMS, Bellary, Karnataka, India.
  • RAVINDRA MARADI Department of Biochemistry, Manipal University, KMC, Manipal, India.
  • ANIL B Department of Biochemistry, SDMCMSH, Dharwad, Karnataka, India.
  • BEENA V. SHETTY Department of Biochemistry, Manipal University, KMC, Mangalore, India.

Keywords:

Epilepsy, AOPP, Protein Carbonyl, Antioxidants

Abstract

        The main aim of this study was to evaluate the role of Plasma advanced oxidation protein product (AOPP), protein carbonyl as indicator of oxidative stress and reduced glutathione, total thiols, albumin as antioxidant status among epileptics. 25 patients with history of epilepsy on treatment in the age group of 20-60 years were compared with 25 normal healthy controls of same age group. There was highly significant increase in AOPP (P=0.002) and protein carbonyl (p=0.001), with significantly decreased antioxidants such as reduced glutathione (p=0.007), total thiols (p=0.023) and albumin (0.01) were noted among epileptics when compared to healthy controls. From this study it could be concluded that increased oxidative stress and reduced antioxidants may be associated with pathophysiology of epilepsy.  

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Published

30.09.2011

How to Cite

RAKESH MUDARADDI, RAMESH, SAMEER, AMARESHWARA M, RAVINDRA MARADI, ANIL B, & BEENA V. SHETTY. (2011). Evaluation Of Oxidative Stress And Antioxidant Status In Patients With Epilepsy. International Journal of Pharma and Bio Sciences, 2(3), 304–309. Retrieved from https://ijpbs.net/index.php/journal/article/view/960

Issue

Volume 2, Issue 3, 2011

Section

Research Articles

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