Hepatoprotective Effect Of Cassia Sophera Leaves Extract Against Paracetamol Induce Hepatic Injury In Rats.

Authors

  • WANKHADE P.W Manoharbhai Patel Institute of pharmacy, (B.Pharm) Gondia, University of Nagpur, India
  • NAGORE D. H Tulip lab Pvt. Ltd. Pune, Pune.
  • KOTAGALE N. R S.K.B College of Pharmacy, University of Nagpur, India
  • TURASKAR A. O Manoharbhai Patel Institute of pharmacy, (B.Pharm) Gondia, University of Nagpur, India
  • MORE S. M Manoharbhai Patel Institute of pharmacy, (B.Pharm) Gondia, University of Nagpur, India

Keywords:

Cassia sophera, Paracetamol, biochemical parameters and hepatotoxicity.

Abstract

Ethanol extract of Cassia sophera (Caesalpiniaceae) was evaluated for hepatoprotective activity in rats. The plant extract (500 mg/kg, p.o.) showed a remarkable hepatoprotective activity against paracetamol induced hepatotoxicity as judged from the serum markers for liver damage. Paracetamol induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and decrease in total protein. Treatment of rats with ethanol extract (500 mg/kg) significantly altered serum marker enzymes levels to near normal against paracetamol treated rats. The activity of the extract was comparable to the standard drug Liv-52 (5 ml/kg, p.o.) Histopathological changes of liver sample were compared with respective control. Results indicate that Cassia sophera possesses hepatoprotective effect on paracetamol induced hepatotoxicity in rats.

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Published

30.09.2011

How to Cite

WANKHADE P.W, NAGORE D. H, KOTAGALE N. R, TURASKAR A. O, & MORE S. M. (2011). Hepatoprotective Effect Of Cassia Sophera Leaves Extract Against Paracetamol Induce Hepatic Injury In Rats. International Journal of Pharma and Bio Sciences, 2(3), 433–438. Retrieved from https://ijpbs.net/index.php/journal/article/view/917

Issue

Volume 2, Issue 3, 2011

Section

Research Articles

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