Synthesis And Cytotoxicity Evaluation Of Diarylpyrazine And Dihydropyrazine Derivatives

Authors

  • PARISA MIRALINAGHI Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • MONA SALIMI Department of Physiology and Pharmacology, Pasture Institute of Iran (NCBI) Tehran, Iran.
  • SARA SHIRMOHAMMADLI Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • MOHSEN AMINI Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Keywords:

Diarylpyrazine, Diaryldihydropyrazine, Cytotoxicity, MT-29,

Abstract

Some 2,3-diaryl pyrazines and 5,6-diaryl-2,3-dihydropyrazine were synthesized and evaluated for their cytotoxicity study. 2,3-Diarylpyrazines were prepared from oxidation of 5,6-diarly-2,3-dihydropyrazine by sulfur. The synthesized compounds were tested for their cytotoxicity effects toward (MT-29) cancer cell line using MTT-assay. The results showed compounds 4a and 4b were two most active compounds.  

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Published

30.09.2011

How to Cite

PARISA MIRALINAGHI, MONA SALIMI, SARA SHIRMOHAMMADLI, & MOHSEN AMINI. (2011). Synthesis And Cytotoxicity Evaluation Of Diarylpyrazine And Dihydropyrazine Derivatives. International Journal of Pharma and Bio Sciences, 2(3), 60–64. Retrieved from https://ijpbs.net/index.php/journal/article/view/877

Issue

Volume 2, Issue 3, 2011

Section

Research Articles

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