Anticancer Activity Of Petroleum Ether Extract Of Abrus Precatorius On Ehrlich Ascitis Carcinoma In Mice

Abstract

This investigation aims to evaluate the Anti tumour potential of the petroleum ether extract of Abrus precatorius Linn (PEEAP) on Ehrlich Ascitis Carcinoma (EAC) tumour model. Tumour was induced in mice by intraperitoneal injection of EAC cells (1 ×10⁶cells/mouse). PEEAP was administered to the experimental animals at the dose levels of 250,500 and 1000 mg/kg per day after 24 hrs of tumour inoculation. The anti tumour effect of PEEAP was evaluated by assessing and body weight, survival time, haematological parameters. Oral administration of PEEAP increased the survival time of the EAC bearing mice. The PEEAP brought back the alter levels of the haematological parameters in a dose dependent manner in EAC bearing mice. The results were comparable to that of the result obtained from the animals treated with the standard drug 5-flurouracil (20mg/kg .b.w). Thus present study revealed that PEEAP possessed significant anti tumour activity.