Glycemic Effect of Freeze Dried Murraya Koenigii - An Evidence Based Study

Abstract

The scientific evaluation of hypoglycemic and antidiabetic activity of freeze dried leaves of Murraya koenigii was carried out in normal and Streptozotocin-induced sub- and mild- diabetic rats. A single oral administration of variable doses of 100, 200, 300 and 400 mg kg-1 lowered Blood Glucose Level in normal and diabetic rats. A fall of 41.5% in normal, 34.3% in sub-diabetic and 37.9% in mild-diabetic rats was observed with the dose of 300 mg kg-1 after 6 h of oral administration. Same dose also improved glucose tolerance as indicative from the fall of 38.7% in normal, 54.3% in sub-diabetic and 51.7% in mild-diabetic rats in Glucose Tolerance Test after 3 h. The findings of glycemic and phytochemical studies suggest that the identified phytochemicals might be responsible for its glycemic effect and hence, the freeze dried powder may be prescribed as adjunct to dietary therapy and drug treatment for managing diabetes mellitus.