Association Of TNF-Α With Obesity In Type 2 Diabetes Mellitus

Abstract

Recent work in the area of Obesity has confirmed that Obesity is a state of low  grade chronic inflammation and is associated with  increased levels of  TumorNecrosisFactor-α, a pro-inflammatory  adipocytokine, which  plays a key role in the pathogenesis of  Diabetes. In this  study  we  analysed  the interrelations between TumorNecrosisFactor-α with anthropometric and clinical variables. The study was carried out on a total of 100 subjects attending outpatient department of General Medicine, Narayana Medical College, Nellore. Serum TumorNecrosisFactor-α was measured by sandwich  ELISA  method and insulin by  chemiluminescence method.  TumorNecrosisFactor-α was significantly elevated   in diabetic cases[215.18+ 119.58] compared to controls[p= 0.0001]. There was significant positive correlation between TumorNecrosisFactor-α and Body Mass Index. TNF alpha levels were significantly elevated in obese than in non-obese diabetic subjects. Our results suggest a possible role of TNF-alpha in the pathophysiology of  Type2 Diabetes mellitus.