Synthesis and Antibacterial Activity of Some New Chalcones and Flavones Having 2-Chloro-8- Methoxyquinolinyl Moiety

Authors

  • S.S.MOKLE 1Laboratory of Organic Synthesis, P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India-431602.
  • S.V.KHANSOLE 1Laboratory of Organic Synthesis, P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India-431602.
  • R.B.PATIL Department of Botany, Yeshwant Mahavidyalaya, Nanded, India.
  • Y.B. VIBHUTE 1Laboratory of Organic Synthesis, P.G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded (M.S.) India-431602.

Keywords:

2-chloro-8-methoxy-quinoline-3-carbaldehyde, halohydroxysubstitued acetophenones, chalcones, flavones, antibacterial activity.

Abstract

New chalcones (3a-h) were synthesized from 2-chloro-8-methoxy-quinoline-3-carbaldehyde (2) and halohydroxysubstitued acetophenones (1a-h) via Claisen-Schmidt condensation. Further new flavones (4a-h) were synthesized by oxidative cyclisation of chalcones (3a-h) using microwave as well as by conventional method. The structures of synthetic compounds were established on the basis of analytical and spectral data. These compounds were screened for their antibacterial activity.

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Published

09.03.2026

How to Cite

S.S.MOKLE, S.V.KHANSOLE, R.B.PATIL, & Y.B. VIBHUTE. (2026). Synthesis and Antibacterial Activity of Some New Chalcones and Flavones Having 2-Chloro-8- Methoxyquinolinyl Moiety. International Journal of Pharma and Bio Sciences, 1(1), 1–7. Retrieved from https://ijpbs.net/index.php/journal/article/view/8

Issue

Volume 1, Issue 1, 2010

Section

Research Articles