Simultaneous Estimation Of Ambroxol Hydrochloride And Loratadine In Tablet Dosage Form By Using UV Spectrophotometric Method

Authors

  • ILANGOVAN PONNILAVARASAN College Of Pharmacy, Kovai Medical Centre Research And Educational Trust, Coimbatore,641048, India.
  • CHEBROLU.SUNIL NARENDRA KUMAR College Of Pharmacy, Kovai Medical Centre Research And EducationalTrust, oimbatore,641048, India.
  • P.ASHA College Of Pharmacy, Kovai Medical Centre Research And Educational Trust, Coimbatore,641048, India.

Keywords:

Ambroxol , Loratadine, Simultaneous equation method, Uv spectroscopy.

Abstract

A novel, simple, rapid, precise, accurate, cost effective and reproducible spectrophotometric   method has been developed for simultaneous estimation of ambroxol hcl and  loratadine in combined tablet dosage form. The method employs measurement of absorbance at two wavelengths,308nm and 245nm, of ambroxol and loratadine respectively.   Beer´s law obeyed in the concentration range of 10-50µg/ml  and  10-50µg/ml  for ambroxol and  loratadine respectively.. The proposed method is recommended for routine analysis since it is rapid, simple, accurate, and also sensitive and specific. Results of  percentage  recovery studies confirmed the accuracy of the proposed method.  The present uv spectroscopic method was validated following  the ICH guidelines17-18.

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Published

31.03.2011

How to Cite

ILANGOVAN PONNILAVARASAN, CHEBROLU.SUNIL NARENDRA KUMAR, & P.ASHA. (2011). Simultaneous Estimation Of Ambroxol Hydrochloride And Loratadine In Tablet Dosage Form By Using UV Spectrophotometric Method. International Journal of Pharma and Bio Sciences, 2(2`), 338–344. Retrieved from https://ijpbs.net/index.php/journal/article/view/781

Issue

Volume 2, Issue 2, 2011

Section

Research Articles

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