Development And Validation Of RP-HPLC Method For The Estimation Of Strontium Ranelate In Sachet

Authors

  • K.MYTHILI Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
  • S.GAYATRI Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
  • KOYA RAVI TEJA Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
  • K.CHITRA Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India
  • C.UMA MAHESWARA REDDY Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

Keywords:

Strontium ranelate, RP- HPLC, UV detection, Validation

Abstract

A rapid and sensitive RP-HPLC method with UV detection (323 nm) for routine analysis of strontium ranelate in bulk and in pharmaceutical formulation as sachet was developed. Chromatography was performed with mobile phase containing a mixture of monobasic potassium phosphate buffer and methanol (3:1 v/v) with the flow rate of 0.8 ml/min at 25 º C. In the range of 50-250 μg/ml, the linearity of strontium ranelate shows a correlation coefficient of 0.999. The percentage recovery studies were found to be in the range of 97-102 %. The proposed method was validated by determining accuracy, precision and ruggedness. The results of all the validation parameters were well within their acceptance values.

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Published

31.03.2011

How to Cite

K.MYTHILI, S.GAYATRI, KOYA RAVI TEJA, K.CHITRA, & C.UMA MAHESWARA REDDY. (2011). Development And Validation Of RP-HPLC Method For The Estimation Of Strontium Ranelate In Sachet. International Journal of Pharma and Bio Sciences, 2(2`), 258–263. Retrieved from https://ijpbs.net/index.php/journal/article/view/769

Issue

Volume 2, Issue 2, 2011

Section

Research Articles

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