Evaluation Of Protective Effect Of Delonix Elata On Chronic Inflammation And Comparison Of Its Ulcerogenic Potential With Ibuprofen.

Abstract

Antinociceptive property of ethanolic extract of plant Delonix Elata was  screened  by  acetic  acid  induced  writhing  in  mice while the anti-inflammatory property against chronic inflammation was  studied using cotton pellet granuloma in  rats. The  gastric  irritant  action  was  tested  by  administering  the  drug  orally  and  screening  the  gastric  mucosa  macroscopically  and  microscopically in  rats. The  severity  of  ulcers  were  scored  from  zero  to  five.  Plant extract of Delonix elata, at the dose 100 and 200 mg/kg showed significant reduction in the number of writhing with 55.56% and 54.76% of inhibition respectively along with significant dose dependent reduction in the weight of cotton pellet from 48.7 mg to 31.3 mg and 28.5 mg respectively. The results were comparable to the standard drug, Ibuprofen. The  histological  section  after  administration  of  Ibuprofen  indicated  superficial  erosion,  in  contrast  to intact surface epithelium after  treatment  with  D.elata.