Enhancement Of Dissolution Rate Studies On Solid Dispersion Of Aceclofenac

Abstract

Aceclofenac  is  a  Non- Steroidal Anti Inflammatory  drug  indicated  for  the  relief  of  pain  and  inflammation, associated  with  rheumatoid  arthritis, osteo  arthritis, ankylosing, spondylitis. The percentage of dissolution rate of drug released from pure Aceclofenac was obtained 26.48% in 180min. The  aim  of  the  study  was  to  enhance  the  dissolution  rate  on  solid  dispersion  of  Aceclofenac  by  using  PEG6000  as carrier  in  three  different  ratios  such  as  ACF:PEG6000-1:1, 1:2 and 1:4 by  fusion  method  or  melting  method. The  percentage  of  drug  release  of  Aceclofenac  from  solid  dispersions   ACF:PEG6000-1:1,1:2 and 1:4  was 59.65%,84.75%,98.34%  respectively  in  180min. Aceclofenac   from  solid  dispersions  due  to  enhancing  effect  of  PEG6000.