Association Of Serum Uric Acid With Insulin Resistance

Abstract

Overweight, obesity which further leads to insulin resistance represents a rapidly growing threat to the health of populations in an increasing number of countries. Obesity leads to Insulin resistance (IR) which is further established by genetic and environmental factors. Insulin resistance leads to impaired glucose tolerance and which further plays an important pathophysiological role in the development of diabetes. Insulin resistance leads to many complications like severe high blood pressure, severe low blood pressure, cardiac diseases, stroke, renal diseases, retinopathies, cancer, Alzheimer’s disease, and other neurological problems. So, it is very important for clinicians to identify obesity and early interference to stop insulin resistance to prevent obese individuals to become diabetic. So, we performed Hospital based case control study and included 75 cases of non-obese and 75 cases of obese pre-diabetic individuals of age between 20-50 years and after performing relevant statistical analysis of obtained data we found that obese individuals have high insulin resistance and there is strong significant association between uric acid and BMI, uric acid and WHR, uric acid and insulin levels, uric acid and HOMA IR (Insulin resistance) in obese prediabetic patients. Our study showed that the mean serum uric acid value in males was 7.44 ± 0.29 while in females it was 7.35 ± 0.43, and the difference was statistically significant in this study. Thus, uric acid could serve as a good & cost-effective marker to predict insulin resistance association of uric acid with BMI, WHR which leads to insulin resistance in people with obesity.