COVID-19 – A Review from Endemic to Pandemic spread of the virus

Abstract

The Covid-19 became the most dreadful disease of the 20^th century shaking the whole world and still fights for the precise cure apart from natural immunological response. Shifting from epidemic to pandemic nature of this virus within a short duration exhibits the severe nature of its threat to mankind. This review is about the initial outbreak of COVID-19 in Wuhan, China possible reason behind the epidemic, sequence of spread from wuhan to other parts on those initial days, hospital reports of Wuhan about their initial  findings of COVID-19 positive cases of Wuhan, World Health Organisation(WHO) steps amd measure for this pandemic, initial steps taken by some countries during those days of outbreak, Clinical symptoms and features of covid 19 confirmed patients with their biochemical parameters, source or origin and its controversies for this virus, Structure and classification of virus, its laboratory isolation techniques, Speed of spread and virulence of this virus, reproduction number, the real causative factor, cell receptors interaction, genomic sequence of the virus done and published by wuhan institute of virology  genetic analysis, bioinformatics study about its interaction over ACE2 receptors, Current existing  treatment with stress on promising and prominent therapeutic agents, treatment development strategies, non pharmaceutical interventions Comparative review with related virus of SARS and MERS, Controlling and future prevention strategies.