Gc-hrms screening & anticancer activity of bioactive compounds from crude extracts of Colletotrichum Gloeosporioides F.SP. Pilosae

Authors

  • RAHAT UBAID ANSARI Department of Botany, Mithibai college, Vile Parle (W), Mumbai – 400 056, India
  • SASHIREKHA SURESHKUMAR Department of Botany, Mithibai college, Vile Parle (W), Mumbai – 400 056, India

DOI:

https://doi.org/10.22376/ijpbs.2019.10.3.b118-127

Keywords:

Garuga; phylloplane fungi; Gas chromatography; anticancer

Abstract

Phylloplane fungi are fungi growing on the surface of the leaf. Leaf and fungi grow in association with each other either symbiotically or asymbiotically. The present investigation explores the presence of potential bioactive compounds present in the leaves of Garuga pinnata and Colletotrichum gleosporoides. The fungus was screened for the presence of bioactive compounds using GC-HRMS. Further these compounds were analysed for anticancer activity against two human cancer cell lines. About 14 bioactive compounds in ethyl acetate of Garuga pinnata leaves & 18 bioactive compounds in the ethyl acetate extracts of Colletotrichum gleosporoides were detected. Colletotrichum showed anticancer activity on cancer cell lines SiHa & SCC – 40 causing 50% inhibition of cell growth of cervical & oral tissues.

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Published

30.09.2019

How to Cite

RAHAT UBAID ANSARI, & SASHIREKHA SURESHKUMAR. (2019). Gc-hrms screening & anticancer activity of bioactive compounds from crude extracts of Colletotrichum Gloeosporioides F.SP. Pilosae. International Journal of Pharma and Bio Sciences, 10(3), 118–127. https://doi.org/10.22376/ijpbs.2019.10.3.b118-127

Issue

Volume 10, Issue 3, 2019

Section

Research Articles

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