Tissue 1, 25-dihydroxycholecalcifrol (DHVD3), vitamin D receptor (VDR) and matrix metalloproteinase-2 (MMP-2) levels in women with uterine leiomyoma(S)

Abstract

Uterine leiomyomas are the most common form of benign uterine tumors. The main purpose of this study is to compare between the levels of 1, 25-Dihydroxyvitamin D₃ (DHVD3), vitamin D receptor (VDR), and Matrix Metalloproteinase-2 (MMP-2) in tissues homogenate of uterine leiomyoma(s) and adjacent normal myometrium. Thirty four women were recruited for this case-control study. For each case, fibroid(s) size was determined. Also, tissue DHVD3, VDR, and MMP-2 levels were measured by ELISA technique. A significant decrease in fibroid tissue homogenate DHVD3 levels was found versus homogenate of normal tissue. Vitamin D receptor and Matrix Metalloproteinase-2 levels revealed insignificance between the fibroid and normal tissues. A reduction of DHVD3 level was obtained in fibroid tissues which represents an important gynecological pathology in women due to its relatively high prevalence and their probable impact on the patient's quality of life.