Excitotoxicity - An important target for neuroprotection

Authors

  • VIKAS VASANT PAWAR PG Student, Dr L H Hiranandani College of Pharmacy, Pharmacology Department, Ulhasnagar-03, Maharashtra, India.
  • RACHANA D. SARAWADE Assistant Professor/H.O.D in Dr L H Hiranandani college of pharmacy, Pharmacology Department, Ulhasnagar-03, Maharashtra, India.

DOI:

https://doi.org/10.22376/ijpbs.2019.10.1.p21-32

Keywords:

Glutamate, Excitotoxicity, Neuroprotection, Parkinson disease, Neuropathic pain.

Abstract

Glutamate is free amino acids that function as an Excitatory Neurotransmitter in the Central Nervous System (CNS). Excess Stimulation of Glutamate receptors i.e. NMDA(N-Methyl-D-Aspartate) receptor by Excitatory Neurotransmitter leading to number of deleterious consequences, such as impairment in Calcium efflux, Free radicals production, Mitochondrial dysfunction and Secondary Excitotoxicity. Excitotoxicity causes motor disorder such as Parkinson’s disease & non motor disorder such as Neuropathic pain. Neuroprotection is the only way to prevent Excitotoxicity. Therefore in this review, we summarize various Neuroprotecting agents preventing motor disorder like Parkinson’s disease & non motor disorder like Neuropathic pain caused due to Excitotoxocity.

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Published

31.03.2019

How to Cite

VIKAS VASANT PAWAR, & RACHANA D. SARAWADE. (2019). Excitotoxicity - An important target for neuroprotection. International Journal of Pharma and Bio Sciences, 10(1), 21–32. https://doi.org/10.22376/ijpbs.2019.10.1.p21-32

Issue

Volume 10, Issue 1, 2019

Section

Review Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.