The protective effect of Nigella Sativa in paracetamol induced liver toxicity in mice

Abstract

Introduction Paracetamol  is a safe and successful analgesic and antipyretic but it  has been endorsed to more than half the cases of acute liver failure in the US and Britain. On the other hand Nigella sativa seeds,  which is belonging to the botanical family of Ranunculaceae of herbaceous plants and known as black cumin seed,  has been in use  for  centuries in Asia, Middle East, and Africa for different medical purposes. It is used as a traditional benefit   for a number of ailments. In pharmaceutical field,   N. sativa conjugated sterols could be used as precursors for the hemisynthesis of many hydrosoluble steroids.  On the other hand Paracetamol has been correlated   to more than half the cases of acute liver toxicity  in the US and Britain. The aim of the Study is  to investigate the possible hepatoprotective effects of N. sativa against  Paracetamol induce hepatotoxicity in mice material and methodsForty  adult male albino mice, included in the experiment and Paracetamol was used to induce hepatotoxicity in a dose of 1 gm /kg by the oral route. evaluation of liver damage was done by many  biochemical and histopathological investigations. The result showed  a potent protective effect of N. sativa against Paracetamol hepatotoxic effect as Nigella sativa in this study tended to normalize the serum levels of liver enzymes, and the protective effects has been observed clearly by the histopathological evaluation confirming that it effectively protected mouse livers against severe damage caused by Paracetamol. Conclusion in our  study it shows that Nigella sativa have a very significant protective effects against paractamol induced liver toxicity which is recommended to be fully investigation on human especially to people on risk of paractamol liver toxicity.