Process Development and Optimization of New Analogues of Isatin

Authors

  • SWAPNA VADLAMANI Assistant Professor, Process Chemistry Department, Niper, Hyderabad.
  • VIDYA SRILEKHA Assistant Professor, Process Chemistry Department, Niper, Hyderabad.

DOI:

https://doi.org/10.22376/ijpbs.2018.9.1.p132-142

Keywords:

Isatin, imidazole, oxiindole, antifugal drugs, antibacterial drugs

Abstract

Isatin and its derivatives possess broader range of biological activity. High bilogical activity and potency of Isatins Motivated our current work which involves synthesis of novel analogues of this natural product. Initial screening of the analogues by molecuar docking studies was carried out by using schordinger software. Best analogues with good glide score and interactions were selected and were synthesized.Optimization studies were carried our for the analogues.Charecterization of the analogues was done using LC-MS and NMR studies and included in the supporting information.

Downloads

Published

31.03.2018

How to Cite

SWAPNA VADLAMANI, & VIDYA SRILEKHA. (2018). Process Development and Optimization of New Analogues of Isatin. International Journal of Pharma and Bio Sciences, 9(1), 132–142. https://doi.org/10.22376/ijpbs.2018.9.1.p132-142

Issue

Volume 9, Issue 1, 2018

Section

Research Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.