Starch coated gold nanoparticles using Hygrophila Auriculata L for controlled released of anticancer drug doxorubicin

Abstract

In this study, we developed encapsulating doxorubicin (DOX) drug loaded starch coated Hygrophila auriculata L mediated gold nanoparticles (H-AuNPs) [DOX loaded starch coated-H-AuNPs]. H-AuNPs were characterized by UV-Visible spectrophotometer, XRD, TEM. The DOX-loaded starch coated-H-AuNPs was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release proï¬le. Additionally, drug entrapment efficacy (EE) was up to 43%; DOX-starch-H-AuNPs showed a pH-responsive drug release in vitro. The DOX release was nearly 79% at pH 5.4 and 68% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery.