Synthesis and antimicrobial activity of some 1, 3- diheteroaryl substituted-propan-1-one derivatives

Abstract

Six new mannich bases were synthesized by reaction between 6-substituted-2amino-benzothiazole and 5-substituted-1-(1H-1,2,4-triazol-1-yl)-ethanone in presence of formaldehyde and conc. HCl. The synthesized compounds were characterized by IR and 1H-NMR spectroscopy. All the synthesized compounds were screened for in vitro antimicrobial activity against the pathogens S. aureus, B. subtilis,  P. aeruginosa, E. coli, A. niger and C. albicans. Few synthesized derivatives were found to exhibit good antimicrobial activity.