Synthesis and characterisation of CU (II) schiff base complex derived from Amoxicillin Trihydrate and Vanillin for antimicrobial application

Abstract

A new metal (II) complex of Schiff base were synthesized from the novel ligand 6-(2-(4-hydroxy-3-methoxybenzylibeneamino)-2-(4-hydroxyphenyl)acetamido)-3,3-dimethy 7oxo 4-thia-1-aza bicycle[3.2.0] heptane-2-carboxylic acid(BAAMOTACA) derived from amoxicillin trihydrate and vanillin and the Schiff base is orange colour solid and having sharp melting point. The metal complex was investigated using spectroscopic techniques IR, ¹H NMR and magnetic measurements. Antibacterial and Antifungal activity of the of Cu (II) Schiff base was done using Agar well diffusion methods. The IR spectra illustrated a bidentate ligand which coordinates through phenolic oxygen atom and imino nitrogen atom from azomethine bond. In ¹H NMR the azomethine proton signals in the spectrum of the Cu-BAAMOTACA (Cu-B) complex is shifted downfield. The molecular weight of the ligand was confirmed by GC-MS analysis and the retention time of the complex was found to be 17.27. The electron paramagnetic resonance spectral lines exhibited tetragonal distortion from axial symmetry, with g_ÇÇ>g⊥ in the copper (II) complexes with diamagnetic behaviour.It may find a strong position in development of new pharmaceuticals especially as antibacterial and antifungal agents.