Role of nuclear factor kappa- b (nf-kb) and its interactionWith hsamicrorna 146A in esophageal cancer

Authors

  • VIPUL CHAUDHARY Department of Biotechnology, Deen Bandhu Chhotu Ram University of Science and Technology,Murthal(Sonepat) Haryana.
  • PAMELA SINGH Department of Biotechnology, Deen Bandhu Chhotu Ram University of Science and Technology,Murthal(Sonepat) Haryana.

DOI:

https://doi.org/10.22376/ijpbs.2017.8.3.b669-673

Keywords:

Esophageal squamous cell carcinoma, miRNA, polymorphism, growth factors, tumor suppressor genes, mutations,oncogenes.

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in the world with extremely poor prognosis due to late presentation and rapid progression. SNPs (single nucleotide polymorphism) or mutations located within the miRNA regions has been shown to change the processing including binding affinity and specificity. miRNAs are acting as modulators or effectors of the NF-kB signalling pathway.  The hereditary link of esophageal cancer is not very clear, there are several oncogenes such as EGFR, ERB2, MYC, CyclinD etc. and tumor suppressor genes e.g. TP53, P16, FHIT, RB, P14/ARF and telomerase have been shown to be involved in esophageal carcinogenesis.

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Published

30.09.2017

How to Cite

VIPUL CHAUDHARY, & PAMELA SINGH. (2017). Role of nuclear factor kappa- b (nf-kb) and its interactionWith hsamicrorna 146A in esophageal cancer. International Journal of Pharma and Bio Sciences, 8(3), 669–673. https://doi.org/10.22376/ijpbs.2017.8.3.b669-673

Issue

Volume 8, Issue 3, 2017

Section

Review Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.