Antibacterial activities of metabolites from Corynebacterium spp. Strains isolated from the reproductive Tract of a healthy woman against human pathogenic bacteria

Abstract

The genus Corynebacterium spp., also known as "diphtheroids" or "coryneform" includes diverse group of microorganisms inhabiting different biotopes of the human body. In this work we have studied the influence of metabolites from Corynebacterium spp. strains isolated from the reproductive tract of a healthy woman on growth, biofilm formation and on developed biofilms (24h grown) K. pneumoniae, E. coli, P. aeruginosa and S. aureus. We found that all human bacterial pathogens showed slower growth in the presence of metabolites of Corynebacterium. All the isolated Corynebacterium strains to inhibit biofilm formation and destroy developed biofilms (24h grown) K. pneumoniae, E. coli, P. aeruginosa and S. aureus. The obtained data reveals the important role of Corynebacteria in protecting the vaginal biotope from infection in those women who do not have Lactobacilli and suggest a probiotic potential of these Corynebacterium strains as an anti-bacterial agent in the vagina.