Formulation and evaluation of floating drug delivery system

Abstract

Floating matrix tablets are designed to prolong the gastric residence time after oral administration at a particular site. It is useful for achieving controlled plasma level as well as improving bioavailability. With this objective, floating dosage form containing clarithromycin as drug was designed for the treatment of Helicobacter pylori infection. Tablets containing hydroxyl propyl methylcellulose (HPMC) drug and different additives were compressed using wet granulation. The study showed that tablet composition and mechanical strength have great influence on the floating properties and drug release. Incorporation of gas-generating agent together with polymer improved drug release, besides optimal floating lag time lass than 30 sec; total floating time less than 6 hrs. The optimized formulation was obtained using 150mg of HPMC K4M gave floating lag time less than 30 sec with a total floating time grater than 6 hrs.