TENELIGLIPTIN – THE NEWEST DPP4 INHIBITOR

Abstract

Teneligliptin is the newest DPP4 inhibitor approved by the regulatory authority for the treatment of
Diabetes mellitus. Teneligliptin [TEN20], is approved in Japan, India, Korea, Argentina and currently
undergoing Phase I trials in the USA and Phase II trials in Europe for the treatment ofT2DM. Teneligliptin
scores over other ‘gliptins’ in being more economical and with better efficacy to control blood glucose and
HbA1C levels. Teneligliptin additionally offers other pharmacological advantages like longer half-life,
lesser IC50 value, tight and extensive binding to the DPP4 enzyme. Teneligliptin has been studies
extensively for its safety and efficacy in various clinical trials conducted internationally. Teneligliptin has
sufficient and adequate clinical data to prove itself as monotherapy and combination therapy with other
Anti-Diabetic agents. No dose adjustment is requires in renal failure but certain studies included dose
reduction in mild to moderate hepatic failure. Certain clinical trials have demonstrated cardio-protective
effects of teneligliptin in T2DM patients with increase in serum adiponectin levels. It is safe and well
tolerated, also weight neutral, have low risk of Hypoglycaemia and are equally efficacious with rare side
effects compared to other gliptins. This review article comprehensively documents the available clinical
and pharmacological data for Teneligliptin in the treatment of Diabetes mellitus.