Kinetics of kojic acid production by using different types of carbon and nitrogen sources under solid state fermentation

Abstract

In the present study, coconut coir was evaluated as an inert support for the production of kojic acid under solid state fermentation using four different production medium as moistening agents for the maximum production of kojic acid. Different parameters such as fermentation time (14days), Particle size (0.5mm), moisture content (80%), pH (4.0), temperature (30°C) and inoculum size (30 ml/100g carrier) were evaluated as optimized conditions. The combination of rich carbohydrates and rich nitrogen substrates produced higher production (M1, 110; M2, 109; M3, 107 and M4104 g/kg) as compared to un-optimized conditions (82, 81, 79and 77 g/kg, respectively).In addition, the yield (M1, 0.11; M2, 0.109; M3, 107 and M4, 0.104 g/g substrate) and productivity (M1, 0.327; M2, 0.324; M3, 0.318 and M4, 0.309 g/kg.h) obtained from the optimization was higher than that obtained from the un-optimized conditions, yield ( 0.082, 0.081, 0.079, 0.079, and 0.077 g/g substrate, respectively) and productivity (0.244, 0.241, 0.235, and 0.229 g/kg.h, respectively).