Study of urine microalbumin levels in non-diabetic hypertensive patients

Abstract

Hypertension is common, asymptomatic readily detectable disease that leads to lethal complications like stroke, myocardial infarction and renal disease. Microalbuminuria is one of the earliest indicators of kidney injury and is an important cardiovascular risk factor and appears to be a marker of early arterial disease in patients with/ without diabetes and/or hypertension. Therefore, the study was conducted to analyze urine microalbumin levels and lipid profile parameters in non-diabetic hypertensive patients. 100 diagnosed cases of hypertension of age group between 35-60 years were selected. 100 healthy individuals were selected and they formed the control group. Measurements of serum total cholesterol, triglycerides, HDL-c, LDL-c by using standard enzymatic kits and urine microalbumin by immunoturbidimetric method were carried out using Beckman coulter auto analyzer. Non- diabetic hypertensive patients showed a significant increase in urine microalbumin levels compared to control group. Microalbumin levels found to correlate positively with LDL-c. The finding suggest that microalbuminuria can be used as a predictor for the early detection of cardiovascular and renal changes along with the lipid profile parameters to prevent the mortality.