Preparation and characterization of chitosan/ Polyethylene glycol dendrimeric polymer Composite for controlled release of Cyclophosphamide drug

Abstract

Despite advances in polymeric nanoparticles (NPs) as effective delivery systems for anticancer drugs, rapid clearance from blood and poor penetration capacity in heterogeneous tumors still remain to be addressed. Here, novel chitosan hydrogels were successfully prepared by chitosan /polyethylene glycol with G (5)-NH₂ PAMAM dendrimer. The structure and morphology of hydrogels were characterized by XRD and scanning electron microscopy (SEM). The swelling properties of the hydrogels were investigated in solutions of pH 1.0 and 7.4. The hydrogels showed good swelling capacities and pH-sensitive swelling properties. The swelling studies have been carried out at different drug loading. Swelling study is an important parameter to predict the diffusion of the drugs from the matrix. The drug release was investigated at different pH medium, and it was found that the drug release depends upon the pH medium as well as the nature of matrix.