Renal and hepato protective effects of green tea (camellia sinensis) extract on wistar rats treated with sodium oxalate

Abstract

Nowadays different foods and vegetables are contaminated with oxalates of sodium and calcium, present in pesticides and chemical fertilisers. Even many drugs contain sodium oxalate, which is a causative agent of urolithiasis and hepatic cell damage. Herbal plant supplements may reduce this drug induced toxicity. Renal  and  hepatoprotective  effects  of the aqueous  extracts  of  green  tea  (Camellia sinensis)  were  studied  in  sodium  oxalate  treated  rats. Green tea extract was administered orally to Wistar rats for 20 days, exposed to sodium oxalate in different doses (100 mg/kg body weight and 200 mg/kg body weight. It was administered at a dose of 100 mg/kg body weight, which caused hepatic and renal cell damage. As a result, the different stress marker enzyme activity (Aspartate Transaminase, Alanine Transaminase and Alkaline Phosphatase) were increased.  Green tea extract have an ameliorative effect on sodium oxalate induced damage and can also reduce the tissue cholesterol level in both liver and kidney.