Synthesis, characterization and biological studies of schiff bases metal complexes co(ii), zn(ii), ni(ii), and mn(ii) derived from amoxicillin trihydrate with various aldehydes

Abstract

In the present investigation some new Schiff bases derived from Amoxicillin trihydrate with Cinnamaldehyde and p-Chlorobenzaldehyde and their complexes with bivalent transition metal ions viz. Co(II), Zn(II), Ni(II), and  Mn(II), have been synthesized. The ligand and their metal complexes were characterized on the basis of elemental analysis and micro analytical datas. Shift in the characteristic spectral frequency of the metal complexes, confirms the coordination through metal ion with azomethine group. They were screened for antibacterial activity against several bacterial strains namely E. coli(-), S. aureus(+)  M. luteus(+) and B. lichenformis(+) (ATCC), the metal complexes showed enhanced antibacterial activity compared to uncomplexed ligand.