ROLE OF THE IMMUNE SYSTEM IN THE BIOLOGY OF AUTISM SPECTRUM DISORDERS

Authors

  • BHUVANESH SUKHLAL KALAL Department of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangalore-575018, IndiaYenepoya Research Centre, Yenepoya University, Mangalore-575018, India
  • SHAM S BHAT Department of Paedodontics, Yenepoya Dental College, Yenepoya University, Mangalore-575018, India
  • VINITHA RAMANATH PAI Department of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangalore-575018, India
  • VEENA KM Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya University, Mangalore-575018, India
  • ANIL KAKUNJE Department of Psychiatry, Yenepoya Medical College, Yenepoya University, Mangalore-575018, India

Keywords:

Autism Spectrum Disorders; Autoantibodies; Cytokines; Immunoglobulin; Neurological comorbidities

Abstract

Discovery of autoantibodies that target brain proteins in autistic children and their mothers is an interesting finding. The circulating maternal autoantibodies directed towards fetal brain proteins are highly specific for autism. Furthermore, cellular immune system in autistic children suggests that there may be a defect in signaling pathways that are shared by the immune and central nervous systems. Exploration of the role of immune system in neural development is of great interest in recent research, which may have profound implications for diagnosis and treatment of autism. This review is focused on the most recent research concerning the potential role of immune system dysfunction in autism.

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Published

30.09.2016

How to Cite

BHUVANESH SUKHLAL KALAL, SHAM S BHAT, VINITHA RAMANATH PAI, VEENA KM, & ANIL KAKUNJE. (2016). ROLE OF THE IMMUNE SYSTEM IN THE BIOLOGY OF AUTISM SPECTRUM DISORDERS. International Journal of Pharma and Bio Sciences, 7(3), 853–859. Retrieved from https://ijpbs.net/index.php/journal/article/view/5312

Issue

Volume 7, Issue 3, 2016

Section

Review Articles

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