ANTIMICROBIAL ACTIVITY OF SECONDARY METABOLITES FROM CHAETOMIUM CUPREUM-SS02 ISOLATED FROM SOIL

Abstract

The antimicrobial efficacy of methanol, ethyl acetate, chloroform and butanol extracts of fungus
Chaetomium cupreum was determined by employing well diffusion and broth micro-dilution techniques.
Chaetomium species are the largest genus of saprophytic ascomycetous fungus, which belongs to the
class Sordariomyetes and family Chaetomiaceae. Ethyl acetate and butanol extracts exhibited
antibacterial activity against four bacteria, Staphylococcus aureus, Salmonella typhi, Proteus vulgaris,
Bacillus subtilis tested. In the butanol extract, all the four bacteria exhibited antibacterial activity with zone
of inhibition ranging from 12.0 to 18.5mm at 0.5mg/ml concentration. In the butanol extract, the most
susceptible organism was found to be B. subtilis followed P. Vulgaris,S. typhi and S. aureus Whereas in
ethyl acetate extract, all the four bacteria exhibited antibacterial activity with zone of inhibition ranging
from 13.5 to 17.0 mm at 0.5mg/ml concentration. The most susceptible organism was to found be P.
Vulgaris followed by B. subtilis, S. typhi and S. aureus