SYNTHESIS , CHARACTERISATION AND ANTIBACTERIAL ACTIVITY OF SOME NOVEL ISOXAZOLES, PYRIMIDINTHIONES AND PYRIMIDINONES

Authors

  • ANJANI N. SOLANKEE Department of Chemistry, B. K. M. Science College, Valsad-396001 (Affiliated to The Veer Narmad South Gujarat University,Surat- 395007). India
  • GHANSHYAM A. PATEL Department of Chemistry, B. K. M. Science College, Valsad-396001 (Affiliated to The Veer Narmad South Gujarat University,Surat-395007). India

Keywords:

Isoxazoles, Pyrimidinthiones, Pyrimidinones, Spectral data, Antibacterial activity.

Abstract

The title compounds (7a-e), (8a-e) and (9a-e) have been prepared from chalcones (6a-e)
having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride
in the presence of alkali give isoxazoles (7a-e). Chalcones (6a-e) on condensation with
thiourea and urea in the presence of alkali give pyrimidinthiones (8a-e) and pyrimidinones
(9a-e) respectively. Structures of newly synthesised compounds were established on the
basis of their elemental analysis, IR and 1H NMR spectral data. All the synthesised
compounds have been screened for their antibacterial activity.

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Published

30.09.2010

How to Cite

ANJANI N. SOLANKEE, & GHANSHYAM A. PATEL. (2010). SYNTHESIS , CHARACTERISATION AND ANTIBACTERIAL ACTIVITY OF SOME NOVEL ISOXAZOLES, PYRIMIDINTHIONES AND PYRIMIDINONES. International Journal of Pharma and Bio Sciences, 2(1), 163–169. Retrieved from https://ijpbs.net/index.php/journal/article/view/519

Issue

Volume 2, Issue 1, 2011

Section

Research Articles