COMPARATIVE FREE RADICAL SCAVENGING ACTIVITY OF ANGIOTENSIN RECEPTOR BLOCKERS

Authors

  • ANANDPRIYA V.V.M Demonstrator, Department of Pharmacology, Sri Ramachandra Medical College & Research Institute, Porur, Chennai - 600116.
  • DARLING CHELLATHAI DAVID Professor & Head, Department of Pharmacology, Sri Ramachandra Medical College & Research Institute, Porur, Chennai - 600116.

Keywords:

Telmisartan,Valsartan,Oxidative stress,Antioxidant property.

Abstract

Angiotensin receptor blockers (ARBs) are used in various disease conditions such as hypertension, heart failure and diabetic nephropathy. Telmisartan, Valsartan are potent ARBs and specific competitive antagonist of angiotensin AT1 receptors. Oxidative stress has a vital role in the pathogenesis of hypertension, diabetes mellitus, and cardiac failures. In this study, the antioxidant potential of Telmisartan and Valsartan was evaluated and compared using DPPH assay. It was found out that both these drugs have antioxidant properties and Valsartan has better antioxidant property than Telmisartan. In conclusion, the antioxidant property of the above ARBs could be beneficial in preventing complications in various disease conditions due to oxidative damage.

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Published

30.09.2016

How to Cite

ANANDPRIYA V.V.M, & DARLING CHELLATHAI DAVID. (2016). COMPARATIVE FREE RADICAL SCAVENGING ACTIVITY OF ANGIOTENSIN RECEPTOR BLOCKERS. International Journal of Pharma and Bio Sciences, 7(3), 81–83. Retrieved from https://ijpbs.net/index.php/journal/article/view/5156

Issue

Volume 7, Issue 3, 2016

Section

Research Articles

Categories

License

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