DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR ESTIMATION OF ESCITALOPRAM OXALATE IN TABLET DOSAGE FORMS

Authors

  • SYAMA SUNDAR.B Department of Pharmacy, Acharya Nagarjuna University, Nagarjuna Nagar,Guntur -522 510. INDIA.
  • SUNEETHA.A Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur -522 002. INDIA.

Keywords:

Escitalopram oxalate; anti-depressant; HPLC; validation.

Abstract

A simple, specific, accurate and precise RP-HPLC method was developed and
validated for the determination of escitalopram oxalate in tablet dosage forms. A hypersil
BDS C8, 5- column having 250x4.6mm internal diameter in isocratic mode with mobile
phase containing methanol: disodium hydrogen phosphate: acetonitrile (28:44:28v/v, pH
7.0±0.05) was used. The flow rate was 1.5ml/min and effluents were monitored at
226nm. The retention time of escitalopram oxalate was 8.45 min. The linearity range is
250-1500-g/ml with coefficient of correlation 0.9999. The method was validated in terms
of accuracy, precision, repeatability. The percentage recovery for escitalopram oxalate
was found to be 99.0%. The proposed method was successfully applied for quantitative
determination of escitalopram oxalate in single dosage form for routine analysis.

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Published

30.09.2010

How to Cite

SYAMA SUNDAR.B, & SUNEETHA.A. (2010). DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR ESTIMATION OF ESCITALOPRAM OXALATE IN TABLET DOSAGE FORMS. International Journal of Pharma and Bio Sciences, 2(1), 140–146. Retrieved from https://ijpbs.net/index.php/journal/article/view/514

Issue

Volume 2, Issue 1, 2011

Section

Research Articles