A STUDY OF SERUM ADENOSINE DEAMINASE ACTIVITY IN PRE-ECLAMPSIA AND NORMOTENSIVE PREGNANT WOMEN AT TERTIARY CARE HOSPITAL IN KARNATAKA

Abstract

Hypertensive disorders of human pregnancy, such as preeclampsia are a most common medical complication during pregnancy.  The aim of this study was to investigate the adenosine deaminase activity in preeclampsia and healthy normotensive pregnant women. This is a hospital based case –control study. Total 120 subjects (60 cases of preeclampsia and 60 healthy normotensive pregnant women) with single foetus in the third trimester were recruited. The serum samples analysed for adenosine deaminase activity by Giusti G. and Galanti B. method. The serum adenosine deaminase activity was significantly increased in preeclampsia patients (26.15 ±4.95 U/L) as compare to healthy normotensive pregnant women (12.47 ±2.93 U/L). ADA is a marker of altered cellular immunity. The serum ADA is increased in preeclampsia due to enhanced cell mediated immune response and endothelial dysfunction. This increased adenosine deaminase activity may be predictive to assess the disease severity in preeclampsia.