Current trends in ndds with special reference to NSAIDs

Abstract

Transdermal drug delivery system has been in existence for a long time. Transdermal therapeutic systems have been designed to provide controlled continuous delivery of drugs via the skin to the systemic circulation. Non-steroidal anti-inflammatory drugs used as analgesic, anti-inflammatory and antipyretic in the treatment of rheumatoid arthritis and osteoarthritis, but the clinical use is often limited because of adverse effect such as irritation and ulceration of the gastrointestinal tract. These drugs have a relatively short half-life in plasma and have the potential to be delivered topically, it also has low molecular weight. NSAIDs are an excellent drug for transdermal delivery. Furthermore, topical administration via the dermal route can bypass disadvantages of the oral route. Therefore, transdermal drug delivery has been considered to be an ideal route for administration of NSAIDs.