EXTRACTION OF VINORELBINE FROM LEAVES OF CATHARANTHUS ROSEUS AND ITS APPLICATION IN TREATING BREAST CANCER USING IN VIVO MOUSE MODELS

Authors

  • GIREESH KAMATH. H Dr. M. G. R. Educational and Research institute, Maduravoyal, Chennai-600095
  • DEECARAMAN Dr. M. G. R. Educational and Research institute, Maduravoyal, Chennai-600095
  • RAMESH KV Center for Postgraduate Studies, Jain University, 18 / 3, 3rd Block, 9th Main, Jayanagar, Bangalore - 560011

Keywords:

Breast cancer, plant extract, nude mice, xenograft, Vinorelbine, tumor volume.

Abstract

Extracts from the leaves of Catharanthus roseus were collected using methanol. Three individual alkaloids were fruitfully separated by TLC, purified using column chromatography and one of them was successfully identified as vinorelbine. Nude mice xenografted with breast cancer cell line MDAMB231 were treated through vinorelbine (30 mg/kg body weight, i.p.). Mice responded to the treatment and showed a significant decrease in the tumor volume in comparison to mice of the control growth. Results shows that the plant extracted vinorelbine may be helpful for treating the breast cancer.

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Published

30.06.2016

How to Cite

GIREESH KAMATH. H, DEECARAMAN, & RAMESH KV. (2016). EXTRACTION OF VINORELBINE FROM LEAVES OF CATHARANTHUS ROSEUS AND ITS APPLICATION IN TREATING BREAST CANCER USING IN VIVO MOUSE MODELS. International Journal of Pharma and Bio Sciences, 7(2), 204–211. Retrieved from https://ijpbs.net/index.php/journal/article/view/5052

Issue

Volume 7, Issue 2, 2016

Section

Research Articles

Categories

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