ANTICOAGULANT AND ANTI-INFLAMMATORY POTENTIALSOF SOME EGYPTIAN MARINE ALGAE

Abstract

Marine algae are significant ingredients to formulate drugs for treating disease as they possess various bioactive potentials. Different marine algae (Laurencia papillosa and  cylindrica (red algae) were collected from Red Sea (Faied and Ein Al-Sokhna- Suez). Ulva fasciata (green algae) was collected from the Mediterranean Sea (Abu-Qir near Alexandria) and Dilophus fasciola (brown algae) was collected from Marsa Matrouh. Phenolics, flavonoids and tannins content of the different algae species were estimated and the ethanol extract of these algae species were evaluated for their role as anticoagulant and anti-inflammatory. The results declared that the highest concentration of phenolics, flavonoids and tannins were detected in D. fasciola followed by G. cylindrica and L. popillosa. U. fasciata and D. fasciola exhibited high anticoagulant activities. Results also markedly demonstrated a  significant increase in anti-inflammatory activity of D. fasciola and G. cylindrica as they recorded inhibition percent 40.62% and 43.64%, respectively at the dose of inhibitor 200 mg/ml. Thus, these bioactive compounds can be characterized and tested the efficacy of the future use for the public. Research institutions should collaborate with industry in order to design and develop suitably appealing products with these bioactive compounds.