Anti Ulcerogenic And Ulcer Healing Studies Of Aqueous Extract Of Pueraria Tuberosa Leaves On Rats

Authors

  • SUMALATHA GINDI Hindu college of pharmacy, guntur-522002, andhrapradesh, india
  • BAHLUL Z AWEN College of pharmacy, al-jabal al-gharbi university, al- zawia, libya
  • CHANDU BABURAO College of pharmacy, al-jabal al-gharbi university, al- zawia, libya
  • MUKKANTI KHAGGA Centre for pharmacy, jnt university, hyderabad, andhrapradesh, india

Keywords:

Pueraria Tuberosa, Pyloric ligation, Cold restrain stress

Abstract

In this study, the anti ulcerogenic effect of water extract obtained from the leaves of Pueraria Tuberosa[PT] was investigated using cold restraint stress(CRU), pyloric ligation(PL) & Ethanol induced (EtOH) induced gastric ulcer models in rats. The treatment with PT at higher dose significantly inhibited gastric lesions induced by CRU (76.6%), PL (80.1%) & EtOH (70.6%) respectively with equal potency of Omeperazole. In addition the effects of PT on H+K+ATPase activity was determined. PT significantly inhibited H+K+ATpase activity in EtOH induced ulcer model. PT accelerated the healing of EtOH induced ulcers by inhibiting H+K+ATPase activity. 

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Published

31.12.2010

How to Cite

SUMALATHA GINDI, BAHLUL Z AWEN, CHANDU BABURAO, & MUKKANTI KHAGGA. (2010). Anti Ulcerogenic And Ulcer Healing Studies Of Aqueous Extract Of Pueraria Tuberosa Leaves On Rats. International Journal of Pharma and Bio Sciences, 1(4), 657–661. Retrieved from https://ijpbs.net/index.php/journal/article/view/500

Issue

Volume 1, Issue 4, 2010

Section

Research Articles